The fungal infection from Naughty Dog’s survival horror classic The Last Of Us is a terrifying prospect. Humans who become infected by the parasitic fungus lose higher brain functions, before losing their sight and eventually succumbing to the disease. All the while, infected humans become highly aggressive, and are able to spread the parasite through bites and airborne spores.
The most horrifying thing about the Cordyceps Brain Infection is that it is based on a real-world parasite. Ophiocordyceps unilateralis is a fungal parasite that takes control of ants, and was the inspiration behind the plot of The Last Of Us. According to Naughty Dog, the version of the infection in-game is a mutated variant of its real-life cousin.